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Literature summary extracted from

  • Yu, J.; Li, Y.; Wang, T.; Zhong, X.
    Modification of N6-methyladenosine RNA methylation on heat shock protein expression (2018), PLoS ONE, 13, e0198604 .
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.348 Homo sapiens Q86U44 and Q9HCE5 Q86U44: METTL3, N6-adenosine-methyltransferase 70 kDa subunit. Q9HCE5: METTL14, N6-adenosine-methyltransferase non-catalytic subunit
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.348 Hep-G2 cell
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 Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.348 METTL3
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 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.1.348 Homo sapiens m6A methyltransferases METTL3 mRNA is decreased in responses to heat shock stress in HepG2 cells down

General Information

EC Number General Information Comment Organism
2.1.1.348 malfunction METTL3 knockdown significantly changes HSP70, HSP60, and HSP27 mRNA expression in HepG2 cells using siRNA. mRNA lifetime is not impacted. Knockdown of METTL3 changes the methylation patterns of heat shock proteins transcript Homo sapiens
2.1.1.348 physiological function m6A RNA methylation by METTL3 regulates heat shock protein gene expression Homo sapiens